ANTICLOT ANTICLOT ASCARD ASCARD ASCARD PABFIN EPRIN EPRIN PANARINE EMPIRIN COMP LOPRIN LOPRIN LOPRIN ASPIRIN ASPIRIN ASPIRIN COMPOUND IODOPYRIN ASPIRIN ASPIRIN ASPIRIN ASPIRIN COMPOUND NOVOPRIN PANCOM PANCOM MASPRIN MASPRIN MEPROGESIC ORPHAGESIC ASPIRIN ANAPRIN ANAPRIN ANAPRIN DOLOPRIN-75 ASPIRIN FEBRINOL COMP FEBRINOL COMP SOLPRIN SOLPRIN DONAMOL PLUS DONAMOL PLUS DONAMOL PLUS DONAMOL PLUS ASPRO DISPIRIN DIRECT DISPRIN-CV DISPRIN DISPRIN DISPRIN MEPOL VIN VIN VIN MYPRIN SEMOPYRIN SEMOPYRIN ASPIRIN PARACETAMOL COMPOUND PARACETAMOL COMPOUND ASPIRIN SARAPYRINE SARAPYRINE TRIGESIC ZEPYRINE ASPIDIS PARACETAMOL COMPOUND PARACETAMOL COMPOUND EPLACIN ASPIRIN ASPIRIN LISKOPRIN ASPIRIN ASPIRIN ASPIRIN ASPIRIN MEDIPRIN NUSEALS ASPIRIN SCHAZOPYRIN PANARIN KANAPRIN APISCOT APISCOT ASA ASA ASA VASPRIN PANOGESIC ASPIRIN DEERIN ECOTRIN MINI PRIN PROSPERIN PROSPERIN ASPIRIN DISPERSIBLE ASPIRIN SOLUBLE ASPIRIN PAXFIN DISPIRIN-CF ASPIRIN JUVAPYRINE ASKPRIN ASKPRIN KAPRIN COMPOUND KAPRIN COMPOUND ASCOGIN ASPIWAN ASRIN ASRIN ASRIN ASPISAFE ASPISAFE ASPIRIN PANAM PLUS PANAM PLUS EROCID EROCID EROPYRIN EROPYRIN ASCAMOL ASCAMOL ASPIRIN ASPIRIN DISPRIN MAX ASKPRIN-S ANGIPRO KAYCIGIN PARACETAMOL COMPOUNDS PARACETAMOL COMPOUNDS CARDRIN CARDRIN CLOTNIL CLOTNIL SALETO RESCARD NOPAIN ADALGIN APECIRIN ASPIRIN COMPOUND ASPIRIN COMP ASPIRIN COMP SYNOPAR DARD ARAM MEGAPRIN DISPRIN COLD "N" FEVER NOCLOT-EA PROTOCARD PLUS NORPLAT S ORDOGRIL PLUS LEXPRIN ORSPRINE FLEXI PLUS FLEXI PLUS APCOM CLOPID ASP CLOPID ASP CASPIA CV- 150 CV-75 SOLUPRIN SOLUPRIN SOLUPRIN ASCARD PLUS OGREL PLUS 81 OGREL PLUS 162 DISCLOT PLUS CLODRIL PLUS CLODRIL PLUS CLOPIDO PLUS CLOPIDO PLUS PROGREL AP PROGREL AP ROSPRIN BLOPRIN CLOPIDO PLUS CLOPIDO PLUS DIPRIN GLORIN GLORIN JEPRIN MISPRIN OBSAGREL CLOPIRINE DEPLAT-AP DEPLAT-AP LESBRO LOWPLAT PLUS LOWPLAT PLUS SEACLOP AP SEACLOP AP THROMBONIL PLUS CADCARE PLUS CAPRIN EC CAPRIN EC ASPRIL ROGRIP PLUS MERIPRIN MERIPRIN MERIPRIN PLAGRIL PLUS PLODREL PLODREL

Dose: 0 to 45 mg/kg/d
Single Dose: 22 (22.5)
Frequency: As recommended.
Route: PO
Instructions: for inflammation

Dose: 50 to 75 mg/kg
Single Dose: 62 (62.5)
Frequency: 6 hourly
Route: Oral
Instructions: As Required

Aspirin also known as Acetyl salicylicacid. . It is of Synthetic origin and belongs to Benzoic Acid. It belongs to Cyclo-oxygenase inhibitor pharmacological group on the basis of mechanism of action and also classified in Analgesics and Anti-inflammatory Agents and Salicylate pharmacological group.The Molecular Weight of Aspirin is 180.00. Its pKa is 3.5.

Aspirin is contraindicated in conditions like GI ulceration,Hypoprothrombinemia,Hypersensitivity.

The severe or irreversible adverse effects of Aspirin, which give rise to further complications include Urticaria, Gi bleeding, Rhinitis, Angioneurotic edema, Hepatitis, Hepatomegaly.Aspirin produces potentially life-threatening effects which include Cerebral hemorrhage, Airway obstruction, Gastric ulceration, Gastric erosion. which are responsible for the discontinuation of Aspirin therapy.The signs and symptoms that are produced after the acute overdosage of Aspirin include Coma, Acidosis, Hyperthermia, Volume depletion, Hyperglycemia, Renal failure, Hyperventilation, Cardiovascular collapse, Vertigo, Tinnitus, Hyperkalemia.The symptomatic adverse reactions produced by Aspirin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Nausea, Vomiting, Tinnitus, Epigastric discomfort, Dyspepsia, Asthma, Respiratory alkalosis, Bleeding.

Aspirin is primarily indicated in conditions like Fever, Following coronary bypass surgery, Headache, Inflammation, Ischaemic event (unstable angina, myocardial infarction), Mild to moderate pain, Myocardial infarction, Myocardial infarction prophylaxis, Pain and inflammation (in rheumatic disease, in other musculoskeletal disorders), Prophylaxis of cerebrovascular disease, Pyrexia, Stable angina, Stable angina pectoris, Stroke prophylaxis, and can also be given in adjunctive therapy as an alternative drug of choice in Arterial thromboembolism prophylaxis, Colorectal carcinoma prophylaxis, Juvenile rheumatoid arthritis, Neurogenic bladder, Osteoarthritis.

Aspirin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAcetazolamide (Na)Aspirin displace acetazolamide from plasma protein binding site and reduce renal clearence results in severe metabolic acidosis and/or salicylate toxicity. Acetazolamide change the pH of plasma due to which amount of unionized salicylates increase which may enter in CNS result in coma and death.MajorConcomitant use should be avoided but if necessary monitor the patient`s mental status and acid base balance very carefully.AcrivastineAescinAlcoholAlendronate (Na)AlteplaseIncreased risk of severe bleeding in case of concomitant use.ModerateCarefully monitor signs of bleeding.AnagrelideThe potential risks and benefits of concomitant use of anagrelide with aspirin should be assessed, particularly in patients with a high risk profile for haemorrhage, before treatment is commenced.CilostazoleCorticotropinDeflazacortDesvenlafaxineNSAID or aspirin may potentiate the risk of bleedingcareful mointoring is required at the initiation and discontinution of therapyDiflunisalDipyridamoleDocusate (Na)DorzolamideEnalapril (Maleate)Risk of renal impairment when Aspirin (in doses over 300mg daily) given with ACE inhibitors (e.g Fosinopril), also hypotensive effects antagonized by aspirin and other NSaids by blocking prostraglandins production. the combination of aspirin with enalapril may result in nephrotoxityEnoxaparinIn those Patients receiving enoxaparin, risk of epidural or spinal hematoma become develop which may increase by concomitant use of enoxaparin with aspirin.MajorAspirin should avoid in patients receiving enoxaparin.Strickly monitor the sign and symptoms of neurologic impairement.EplerenoneNSAIDs may possibly reduce the antihypertensive and/or diuretic effects of potassium-sparing diuretics and may increase risk of hyperkalaemia. FenbufenFlurbiprofenAspirin decreases the plasma concentration of flurbiprofen. Aspirin may displace flurbiprofen from plasma protein binding site results in increased concentration of unbound, or free, drug available for clearence.During concomitant therapy, patient should take medication with food.Fosinopril (Na)Aspirin antagonize the hypotensive effect of fosinopril by inhibiting the synthesis of prostaglandin and thus suppressing prostaglandin mediated hemodynamic effect of fosinopril.ModerateIn case of long term therapy blood pressure and renal efficiency should monitor regularly and the lowest therapeutic dosage of aspirin should be used.Fosinopril (Na)Risk of renal impairment when Aspirin (in doses over 300mg daily) given with ACE inhibitors (e.g Fosinopril), also hypotensive effects antagonized.GallopamilGliclazideGlipizideHypoglycemic effect of glipizide may be potentiated by aspirin by stimiulating insulin secretion.ModerateClosely monitor the development of hypoglycaemia.Glyceryl TrinitrateGriseofulvinGriseofulvin decreases the serum concentration of aspirin by interfering its absorptionMinorIf these drugs must be given together , staggered the dose and carefully monitor the level of salicylate.Heparin (Na) and Heparin (Cl)Aspirin enhances anticoagulant effects of Heparin by interfering with platelet adhesion result in increased risk of bleeding.ModerateClose clinical and laboratory observation is recommended for bleeding complication.HirudinHuman InsulinHydrocortisonehydrocortisone increase the bioavailability of aspirinIbuprofenIbuprofen bind reversibly at the active site of platelet cyclogenase and thus competitively inhibit this enzyme but because this binding is reversible so it cause temporary rather than sustained depression of thromboxane formation an thus antagonize the anti-platelet and cardioprotective effect of low-dose aspirin.MajorTake medication with food and immediately report sign and symptoms of GI ulceration and bleeding.IndomethacinIndomethacin bind reversibly at the active site of platelet cyclogenase and thus competitively inhibit this enzyme but because this binding is reversible so it cause temporary rather than sustained depression of thromboxane formation and thus antagonize the anti-platelet and cardioprotective effect of low-dose aspirin.MajorMedications should be taken with food and report the sign and symptoms of GI ulceration and bleeding immediately.Insulin GlulisineInsulin LisproHypoglycaemic effect of insulin may be potentiated by aspirin by stimulating secretion of insulin.ModerateClosely monitor the development of hypoglycemia particularly in advanced age or renally impaired patient. Dose of insulin should be adjusted accordingly.Iopanoic AcidItopride (HCl)Ketorolac (Tromethamine)Concurrent use of ketorolac and aspirin increases the risk of aspirin adverse effects.MajorCoadministration of these agents is considered contraindicated.LepirudinWith any anticoagulant or with thrombolytics in unstable angina.MeclofenamateConcurrent administration of aspirin may lower meclofenamate sodium plasma levels, possibly by competing for protein-binding sites. The urinary excretion of meclofenamate sodium is unaffected by aspirin, indicating no change in meclofenamate sodium absorption. Meclofenamate sodium does not affect serum salicylate levels. Greater fecal blood loss results from concomitant administration of both drugs than from either drug alone.MethazolamideCo-administration may lead to anorexia,lethargy,coma and death.Methohexitone (Na)MethotrexateAspirin reduces the renal elimination of methotrexate and may displace it from binding site, thus increase the pharmacological effect and toxicity of methotrexate.MajorClosely monitor the sign and symptoms of bone marrow suppression and nephrotoxicity.MethylprednisoloneMethyl prednisolone decreases the serum concentration and thus therapeutic effects of salicylates by increaseing renal clearence and inducing hepatic metabolism.ModerateMedications should be taken with food and immediately report the sign and symptoms of GI ulceration and bleeding.MethylprednisoloneMetoclopramide (HCl)Metoprolol (Tartrate)High doses of salicylates alter the antihypertensive effect of beta-blockers by inhibiting the synthesis of prostaglandinMinorMonitor the altered antihypertensive response whenever salicylate is introduced or discontinued.MifepristoneMisoprostolMoexiprilAspirin reduces the hypotensive effect of moexipril by inhibiting prostaglandin synthesis and thus suppressing the prostaglandin mediated hemodynamic effect of moexipril.ModerateMonitor blood pressure regularly and lowest therapeutic dose of aspirin should be used.Nadroparin (Ca)Concurrent use may increase the risk of hemorrhage.Nefopam (HCl)ADVICE: Avoid concomitant use of Aspirin with NSAIDs (increased risk of side effects). NicoumaloneNizatidineIn patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently.Oligomeric ProcyanidinConcurrent use of high doses of OPCs with Aspirin might cause a risk of excessive bleeding. PentoxifyllinePhenoxymethylpenicillin (K)Phenylbutazone Coadministration exacerbate the serious gastrointestinal toxicity. Aspirin at higher doses also decreases the plasma concentration of phenylbutazoneModerateCoadministration should be avoided due to increased risk of toxicity. Patient should take medication with food and should report the sign and symptoms of GI ulceration and bleeding to physician immediately.Phenytoin (Na)Aspirin enhances effects of Phenytoin.PiroxicamCombined use of aspirin with piroxicam aggravate gastrointestinal toxicity. aspirin at higher doses decrease the plasma concentration of piroxicam. ADVICE: Avoid concomitant use of Aspirin with NSAIDs (increased risk of side effects). ModerateDuring concomitant therapy, patient should take medication with food and should immediately report to physician about sign and symptoms of GI ulceration and bleeding.Piroxicam-beta-cyclodextrinThe concomitant use of aspirin and piroxicam produces reduction in the plasma level of PiroxicamPorcine InsulinProbenecidHigh doses of aspirin inhibit the uricosuric effect of probenecid. Aspirin antagonizes effects of probenecid.MinorProtirelinReteplaseConcurrent use may increase the risk of bleeding.Reviparin SodiumAspirin may potentiate the action of Reviparin.RimantadinePeak plasma concentrations and AUC of rimantadine were reduced approximately 10% in the presence of aspirin. RofecoxibConcomitant administration of low-dose aspirin with Rofecoxib may result in an increased rate of GI ulceration or other complications.SalsalateSalsalate, like aspirin, is converted to salicylic acid. Therefore, adding aspirin to salsalate can cause salicylic acid toxicity. SaruplaseSaruplase in combination with aspirin can be given safely to acute myocardial infarction patients.Sodium AcetateAgents that cause urinary alkalinization can reduce serum salicylate concentrations in patients receiving anti-inflammatory dosages of aspirin. The mechanism involves reduction in salicylate renal tubular reabsorption due to increased urinary pH, resulting in increased renal salicylate clearance especially above urine pH of 7. This interaction is sometimes exploited in the treatment of salicylate toxicity.ModeratePatients treated chronically with urinary alkalinizers and large doses of salicylates (i.e. 3 g/day or more) should be monitored for potentially diminished or inadequate analgesic and anti-inflammatory effects, and the salicylate dosage adjusted if necessary.Sodium ValproateStreptokinaseIncreased risk of bleeding.ModerateCarefully monitor the signs of bleeding, during coadministration.SulindacAspirin decreases the plasma concentration of sulindac. Aspirin may displace sulindac from plasma protein binding site results in increased concentration of unbound, or free, drug available for clearence.ModerateDuring concomitant therapy, patient should take medication with food.SulphinpyrazoneAspirin antagonizes effects of Sulphinpyrazone.TenecteplaseAspirin may increase the risk of bleeding if administered prior to, during or after Tenecteplase therapy.Thiopentone (Na)Tiaprofenic AcidAspirin can cause an increased risk of bleeding. Tienilic AcidUrokinaseIncreased risk of severe bleeding.ModerateDuring coadministration, carefully monitor the signs of bleeding.Varicella VaccineVilazodoneNSaids, increase risk of bleedingcareful monitoring should be institutedVortioxetineeither increases effects of other by anticoagulationrisk minimal with low dose aspirinWarfarin (Na)Aspirin may enhance the anticoagulant effect of Warfarin and thus increase the risk of bleeding by inhibiting platelet aggregation.MajorPatients receiving Warfarin should not take Aspirin on an as-needed basis. Nonacetylated salicylates might be safer than Aspirin. Acetaminophen ( 325 mg/day may require more frequent INR monitoring.ZafirlukastAspirin increases plasma concentration of leukotriene antagonists (e.g Zafirlukast).Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Urine tests for Catecholamines, dopa, glucose, ketones, hippuric acid Pregnancy tests carried out on urine Plasma/Serum tests for albumin, barbiturates, calcium, propylthiouracil, tyrosine & uric acid Thyroid Function TestUrine tests for homogentisic acid & homavanillic acid Urine tests for 17-hydroxycorticosteroids & 5-hydroxyindoleacetic acid. hippuric acid,, serum / plasma albumin, calcium, propylthiouracil, tyrosine and uric acid

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Suppositories Store in a well closed container. Refrigeration is recommended. Do not Freeze. Protect from Sunlight and Moisture. Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Moisture.

Aspirin should be used with caution in patients with chronic renal insufficiency, gastric ulcer, severe anemia, and patients intolerant to salicylate. Avoid aspirin in patient with history of blood coagulation defects and if patient taking anticoagulants. Liver function should be monitored in patients receiving large doses of aspirin or in patients with pre-existing hepatic disease in order to prevent reversible, dose dependent hepatotoxicity.